Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as alpha-glycosidase inhibitors
طراحی و سنتز فنوکسی متی بنزویمیدازول با ترکیب مشتقات مختلف آریل تیازول-تریازول استامید به عنوان مهارکننده آلفا گلیکوزیداز
| Title: | Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as alpha-glycosidase inhibitors |
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استنادات
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| Author(s): | Nasli Esfahani, A., Iraji, A., Alamir, A., (...), Hajimiri, M.H., Mahdavi, M. | |
| Published/Type: | 2022 (2022-8-1) / Original Article | |
| Journal: | Molecular Diversity, 26(4), pp. 1995-2009 | |
| Abstract:
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A novel series of phenoxymethybenzoimidazole derivatives (9a-n) were rationally designed, synthesized, and evaluated for their alpha-glycosidase inhibitory activity. All tested compounds displayed promising alpha-glycosidase inhibitory potential with IC50 values in the range of 6.31 to 49.89 μM compared to standard drug acarbose (IC50 = 750.0 ± 10.0 μM). Enzyme kinetic studies on 9c, 9g, and 9m as the most potent compounds revealed that these compounds were uncompetitive... | |
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